فایل ورد (word) مقاله Down-regulation of FR? Inhibits Proliferation and Promotes Apoptosis of Cervical Cancer Cells in Vitro

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 فایل ورد (word) مقاله Down-regulation of FR? Inhibits Proliferation and Promotes Apoptosis of Cervical Cancer Cells in Vitro دارای 10 صفحه می باشد و دارای تنظیمات در microsoft word می باشد و آماده پرینت یا چاپ است

فایل ورد فایل ورد (word) مقاله Down-regulation of FR? Inhibits Proliferation and Promotes Apoptosis of Cervical Cancer Cells in Vitro  کاملا فرمت بندی و تنظیم شده در استاندارد دانشگاه  و مراکز دولتی می باشد.

توجه : در صورت  مشاهده  بهم ريختگي احتمالي در متون زير ،دليل ان کپي کردن اين مطالب از داخل فایل ورد مي باشد و در فايل اصلي فایل ورد (word) مقاله Down-regulation of FR? Inhibits Proliferation and Promotes Apoptosis of Cervical Cancer Cells in Vitro،به هيچ وجه بهم ريختگي وجود ندارد


بخشی از متن فایل ورد (word) مقاله Down-regulation of FR? Inhibits Proliferation and Promotes Apoptosis of Cervical Cancer Cells in Vitro :


سال انتشار : 2014

تعداد صفحات :10

Folate receptor alpha (FR ) mediates folate uptake by endocytosis, and while folate is essential to DNAmethylation and synthesis and may have an important role in proliferating cells. FR is known to be expressedin rapidly proliferating cells, including many cancer cell lines, but there has been no systematic assessmentof expression in cervical cancer cell lines. The aim of the present study was to evaluate the effects of FR onproliferation and apoptosis of cervical cells and correlation mechanism. In this study, we investigated the biologicalfunction of FR in Hela cells using RNA interference. Cell proliferation was evaluated by Cell Counting Kit-8(CCK8) assay, while cell cycling and apoptosis were assessed by flow cytometry, mRNA levels by real time-PCR and protein levels of FR, c-Fos and c-Jun by Western blotting. The results revealed that FR was highlyexpressed in Hela cells and its silencing with a small interfering RNA (siRNA) inhibited cell proliferation andinduced cell apoptosis, arresting the cell cycle in G0/G1 stages while decreasing the proportion in S and G2/Mstages, and suppressed the expression levels of c-Fos and c-Jun. In conclusion, the results of this study indicatedthat FR down-regulation might be capable of suppressing cervical cancer cell proliferation and promotingapoptosis. It suggested that FR might be a novel therapeutic target for cervical cancer.

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