فایل ورد (word) مقاله Association Between Genetic Polymorphism of XRCC1 Gene and Risk of Glioma in ? Chinese Population

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 فایل ورد (word) مقاله Association Between Genetic Polymorphism of XRCC1 Gene and Risk of Glioma in ? Chinese Population دارای 6 صفحه می باشد و دارای تنظیمات در microsoft word می باشد و آماده پرینت یا چاپ است

فایل ورد فایل ورد (word) مقاله Association Between Genetic Polymorphism of XRCC1 Gene and Risk of Glioma in ? Chinese Population  کاملا فرمت بندی و تنظیم شده در استاندارد دانشگاه  و مراکز دولتی می باشد.

توجه : در صورت  مشاهده  بهم ريختگي احتمالي در متون زير ،دليل ان کپي کردن اين مطالب از داخل فایل ورد مي باشد و در فايل اصلي فایل ورد (word) مقاله Association Between Genetic Polymorphism of XRCC1 Gene and Risk of Glioma in ? Chinese Population،به هيچ وجه بهم ريختگي وجود ندارد


بخشی از متن فایل ورد (word) مقاله Association Between Genetic Polymorphism of XRCC1 Gene and Risk of Glioma in ? Chinese Population :


سال انتشار : 2013

تعداد صفحات :6

Background: Gliomas are the most common type of primary brain tumor in adults, and the X-ray repaircomplementing group 1 gene (XRCC1) is an important candidate gene influencing its risk. The objective of thisstudy was to detect the influence of XRCC1 genetic polymorphisms on glioma risk. Materials and Methods: Atotal of 629 glioma patients and 641 cancer-free subjects were enrolled in this case-control study. The genotypesof the c.1471G>A genetic polymorphism were determined by created restriction site-polymerase chain reaction(CRS-PCR) and DNA sequencing methods. The influence of the XRCC1 genetic polymorphism on glioma riskwas evaluated by association analysis. Results: Our data indicated that the alleles/genotype of this genetic variantwas statistically associated with glioma risk. The AA genotype was statistically associated with the increased riskof glioma compared to the GG wild genotype (odds ratios (OR) = 1.89, 95% CI 1.25-2.87, P = 0.003). The allele-Amay contribute to increased the susceptibility to glioma (OR = 1.23, 95% CI 1.04-1.46, P = 0.017). Conclusions:These preliminary findings indicate that the c.1471G>A genetic polymorphism of XRCC1 has the potential toinfluence glioma susceptibility, and might be used as molecular marker for assessing glioma risk.

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