فایل ورد (word) مقاله IL-1? Polymorphism and Expression Associated with Decreased Risk of Gastric Carcinoma: a Case Control Study in the Ethnic Kashmiri Population, India

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توجه : در صورت  مشاهده  بهم ريختگي احتمالي در متون زير ،دليل ان کپي کردن اين مطالب از داخل فایل ورد مي باشد و در فايل اصلي فایل ورد (word) مقاله IL-1? Polymorphism and Expression Associated with Decreased Risk of Gastric Carcinoma: a Case Control Study in the Ethnic Kashmiri Population, India،به هيچ وجه بهم ريختگي وجود ندارد


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سال انتشار : 2015

تعداد صفحات :10

The aim of this research was to investigate the possible association between gastric carcinoma (GC) andpolymorphisms of the IL-1 gene in the Kashmiri population using peripheral blood DNA from 150 gastriccarcinoma cases and 250 population controls with detailed data for clinicopathological characteristics of thedisease. Two SNPs in the IL-1 gene were selected for this study. Expression of IL-1 was studied in 50 gastriccarcinoma cases using immunohistochemistry and RT-PCR and then correlated with genotype. The frequencyof the IL-1-511 C allele was significantly higher in the GC case group (53.3%) than in controls (45.4%) withan odds ratio (OR) of 0.73 and a P value of 0.03. Multivariate regression analysis showed associations of gastriccarcinoma with mutant form of IL-1-511 TT (OR 0.309; P value <0.001) and the CC genotype of IL-1-31(OR 0.313; P value of 0.002). Haplotype analysis of IL-1-31 and IL-1-511 showed decreased association of IL-1-31 T with IL-1-511 C with gastric carcinoma (OR 0.728; P value 0.03). Expression study of 50 samples byimmunohistochemistry (IHC) and RT-PCR showed association with grade III and stage III+IV. After correlatingthe expression with polymorphism no association was found.

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