فایل ورد (word) مقاله Modulation of Drug Resistance in Ovarian Cancer Cells by Inhibition of Protein Kinase C-alpha (PKC-?) with Small Interference RNA (siRNA) Agents

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 فایل ورد (word) مقاله Modulation of Drug Resistance in Ovarian Cancer Cells by Inhibition of Protein Kinase C-alpha (PKC-?) with Small Interference RNA (siRNA) Agents دارای 10 صفحه می باشد و دارای تنظیمات در microsoft word می باشد و آماده پرینت یا چاپ است

فایل ورد فایل ورد (word) مقاله Modulation of Drug Resistance in Ovarian Cancer Cells by Inhibition of Protein Kinase C-alpha (PKC-?) with Small Interference RNA (siRNA) Agents  کاملا فرمت بندی و تنظیم شده در استاندارد دانشگاه  و مراکز دولتی می باشد.

توجه : در صورت  مشاهده  بهم ريختگي احتمالي در متون زير ،دليل ان کپي کردن اين مطالب از داخل فایل ورد مي باشد و در فايل اصلي فایل ورد (word) مقاله Modulation of Drug Resistance in Ovarian Cancer Cells by Inhibition of Protein Kinase C-alpha (PKC-?) with Small Interference RNA (siRNA) Agents،به هيچ وجه بهم ريختگي وجود ندارد


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سال انتشار : 2012

تعداد صفحات :10

Objective: To determine whether silence of PKC- expression by small interference RNA (siRNA) mightregulate MDR1 expression and reverse chemoresistance of ovarian cancer. Methods: We measured gene andprotein expression of MDR1 and PKC- in ovarian cancer cells and assessed their correlation with cell drugresistance. We also examined whether blocking PKC- by RNA interference (RNAi) affected MDR1 expressionand reversed drug resistance in drug sensitivity tests. Results: The drug resistance cell lines, OV1228/DDP andOV1228/Taxol, had higher gene and protein expression of MDR1 and PKC- than their counterpart sensitivecell line, OV1228. SiRNA depressed PKC- gene protein expression, as well as MDR1 and protein expressionand improved the drug sensitivity in OV1228/DDP and OV1228/Taxol cells. Conclusion: These results indicatedthat decreasing PKC- expression with siRNA might be an effective method to improve drug sensitivity in drugresistant cells with elevated levels of PKC- and MDR1. A new siRNA-based therapeutic strategy targetingPKC- gene could be designed to overcome the chemoresistance of ovarian cancer.

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